Arizona visits Indianapolis in Week 6 as underdogs, with Alec Pierce returning and Kenny Moore out, setting up a potentially sharper Colts aerial attack and a nickel spot to monitor in Chris Lammons. The Colts’ front continues to trend toward consistency, led by Laiatu Latu while Grover Stewart’s health adds interior mass. Jonathan Taylor remains a fantasy staple, and Tyler Warren’s mid-range role tightens Indianapolis’ target tree. Kansas City-style efficiency from Steichen’s scheme is noted as a blueprint even in tough losses, boosting fantasy intrigue around Colts playmakers.

Daniel Jones’ breakout efficiency is cited as a blueprint for steady QB performance in similar schemes, underscoring the Colts’ philosophy on game plan and ball distribution. The Cardinals’ offense will test Indy’s pass rush, aiming to keep pace with a trusted, balanced attack. The preview forecasts a tight battle with a projected Colts edge at 24-20, hinging on the Indianapolis defense’s ability to pressure and finish and on Pierce’s impact returning to the field.

Kenny Moore II is out for a third straight Colts game with an Achilles issue, while Alec Pierce clears concussion protocol. Indianapolis’ defensive front features Buckner, Ebukam and Stewart in non-injury designations, with Braden Smith and Charvarius Ward listed but not currently sidelined. On the Cardinals side, Kyler Murray is limited with a foot issue and Zay Jones is knee-questionable; Darius Robinson is out, and several others are limited or questionable, shaping a game with mixed fantasy upside depending on activation and target distribution.

For fantasy managers, Moore’s absence tightens Colts secondary depth; if Arizona’s passing attack is able to push through, Cardinal receivers could see elevated looks, especially if Murray returns to closer to full health. Cardinals’ limited players in the slot and on the edge could hint at opportunistic plays for savvy depth options, while Colt players with clear designations should be approached with caution until full clarity emerges.

Colts lead the Raiders 20-3 at halftime as Jones carves up Las Vegas through the air while the ground game stalls. Tyler Warren breaks through for his first career receiving TD, and a late first-half interception by Laiatu Latu helps keep Indy in control. Spencer Shrader’s knee injury ends his night, trimming Indianapolis’ special-teams punch. The fantasy takeaway centers on Jones’ efficiency and Warren’s breakout, with Taylor’s volume remaining a swing factor.